| Time | Event |
| 1400 | The Lenni Lenape, Native Americans of the Algonkians, settle along the Delaware. |
| 1600 | Minquas, from the Susquehanna River Valley, began to attack the villages of the Lenni Lenape. |
| 1609 | Henry Hudson, an Englishman sailing for the Dutch East India Company, discovers Delaware Bay and River. |
| 1610 | Captain Samuel Argall, an English sea captain, names the bay and river after Lord De La Warr, the governor of Virginia. |
| 1631 | Dutch colonists settle at Zwaanendael (site of present-day Lewes). |
| 1632 | Settlement at Zwaanendael is destroyed and all colonists killed in dispute with Native Americans. |
| 1638 | Peter Minuet leads a group of Swedes to the Delaware and establishes Fort Christina (now Wilmington), the first permanent settlement on the Delaware and the beginnings of the New Sweden Colony. |
| 1639 | The first African on the Delaware, Black Anthony, is brought from the Caribbean to Fort Christina. |
| 1640 | The first Lutheran minister in America, the Reverend Reorus Torkillus, arrives at Fort Christina. |
| 1643 | Johan Printz becomes governor of the New Sweden Colony. |
| 1651 | Peter Stuyvesant, Dutch governor of New Netherland, builds Fort Casimir (now New Castle) just a few miles south of Fort Christina on the Delaware. |
| 1654 | The Swedes capture Fort Casimir and rename it Fort Trinity. |
| 1659 | Lewes is founded. |
| 1655 | The Dutch defeat the Swedes on the Delaware, ending the New Sweden Colony. Delaware becomes a part of New Netherland. |
| 1664 | Sir Robert Carr drives the Dutch off the Delaware and claims the land for James, Duke of York. Delaware becomes an English colony. |
| 1673 | The Dutch regain control of the Delaware. |
| 1674 | The English regain the Delaware |
| 1682 | The Duke of York transfers control of the Delaware Colony to English Quaker William Penn. |
| 1698 | Holy Trinity, Old Swedes Church, is built in Wilmington. |
| 1698- 1700 |
Pirates including Captain Kidd sail along the Delaware. |
| 1704 | Delaware's first assembly of the Three Lower Counties Upon Delaware, separate from Pennsylvania, meets at New Castle. |
| 1717 | Town of Dover laid out. |
| 1731 | Thomas Willing founds Willingtown. |
| 1739 | Willingtown receives royal charter and is renamed Wilmington. |
| 1742 | Oliver Canby builds flour mill on Brandywine River at Wilmington, beginning large commercial flour milling industry. |
| 1761 | James Adams sets up first printing press in Delaware at Wilmington. |
| 1764 | Charles Mason and Jeremiah Dixon survey Delaware's western boundary. |
| 1765 | Caesar Rodney and Thomas McKean represent Delaware at the Stamp Act Congress. |
| 1767-68 | John Dickinson writes Letters from a Farmer in Pennsylvania, an influential protest against British policies towards the colonies. |
| 1774 | Caesar Rodney, Thomas McKean, and George Read represent Delaware at the First Continental Congress. |
| 1776 | June 15: Delaware Assembly declares independence from England. This is the origin of the holiday called Separation Day. |
| July 1-2: Caesar Rodney makes heroic overnight ride from Dover to Philadelphia to cast the vote that put Delaware on the side of independence. | |
| Delaware adopts its first state constitution. | |
| 1777 | Dover replaces New Castle as state capital. |
| Late August-early September: British and American armies are in northern New Castle County. | |
| September 3: Battle of Cooch's Bridge near Newark, only engagement of the war in Delaware. | |
| September 12-British capture Delaware state documents, funds, and President John McKinly after winning the Battle of the Brandywine, then occupy Wilmington until mid October. | |
| 1779 | Delaware Assembly ratifies Articles of Confederation. |
| 1784 | Thomas Coke and Francis Asbury meet at Barratt's Chapel in Frederica, establishing the Methodist Church as a separate denomination in the U.S. |
| 1785 | Oliver Evans builds prototype
automatic flour mill in Newport. Delaware Gazette, state's first newspaper, begins publication. |
| 1786 | Delaware is one of 5 states to send delegates to Annapolis Convention, which hoped to revise the Articles of Confederation. |
| 1787 | December 7: Delaware is the first state to ratify the new U.S. Constitution. |
| 1788-89 | Abolition societies established in Dover and Wilmington. |
| 1791 | The county seat of Sussex County is moved from Lewes to Georgetown. |
| 1792 | Delaware adopts second state constitution. |
| 1795 | Bank of Delaware, the state's first bank, founded in Wilmington. |
| 1798 | British ship DeBraak sinks
off Lewes. Yellow fever epidemic spreads from Philadelphia to Wilmington. |
| 1802 | Du Pont Company is founded when
Eleuthère Irénée duPont de Nemours begins manufacturing gunpowder along the Brandywine River near Wilmington. |
| 1805 | First Methodist camp meeting held near Smyrna. |
| 1807 | Caesar A. Rodney named Attorney General of the United States by President Thomas Jefferson. |
| 1808 | Newport and Gap Turnpike becomes first toll road in Delaware. |
| 1812-13 | Peter Spencer founds the African Union Methodist Protestant Church. AUMP is the first denomination in the nation controlled entirely by African-Americans. |
| 1813 | The British bombard Lewes during
War of 1812. Dr. James Tilton appointed Surgeon General of the U.S. Army. |
| 1814 | Commodore Thomas Macdonough defeats British on Lake Champlain. |
| James A. Bayard is one of American signers of the Treaty of Ghent, ending War of 1812. | |
| Big Quarterly, or August Quarterly, started by Peter Spencer, founder of African Union Methodist Protestant Church, in Wilmington. America's first major black religious festival continues in the 21st century. | |
| 1818 | Construction begins on the mile-long Delaware Breakwater, completed in 1835. |
| 1828 | Steamboat line opens between Philadelphia and New Castle. |
| 1829 | Chesapeake and Delaware Canal opens. |
| Delaware Free School Act passes in legislature creating first public schools in the state. | |
| Louis McLane appointed Secretary of the Treasury of the United States. | |
| 1832 | New Castle and Frenchtown Railroad opens. Covering one and a half miles at first, it used horse cars for nearly a year before switching over to steam service in 1832. |
| Delaware adopts third constitution. | |
| First peach orchard planted in Delaware. State soon becomes major commercial producer of peaches. | |
| 1833 | The University of Delaware is founded as Newark College. |
| Louis McLane appointed Secretary of State of the United States. | |
| 1838 | Philadelphia, Wilmington and Baltimore Railroad opens. |
| 1844 | The Bangor, America's first iron-hulled propeller steamship, launched in Wilmington. |
| 1847 | Delaware Senate considers an act to abolish slavery. The act is defeated by one vote. |
| 1849 | John M. Clayton appointed Secretary of State of the United States. |
| 1852 | Delaware Railroad Company organized. |
| 1855 | State-wide prohibition law enacted; repealed, 1857. |
| 1856 | Delaware Railroad completed to Seaford; to Delmar in 1859. |
| 1861 | Although a slaveholding state, Delaware rejects invitation to join Confederacy. |
| Peace convention at Dover favors peaceable recognition of Confederacy. | |
| Troops from Philadelphia garrison Fort Delaware, which becomes prison camp. | |
| 1862 | Delaware legislature rejects President Lincolns offer to buy its slaves. |
| 1861-65 | More than 12,000 troops from Delaware join Union forces; a small number join the Confederate Army. |
| 1865 | Thirteenth Amendment to the U.S. Constitution abolishes slavery. The Delaware legislature votes against the amendment. |
| 1867 | Howard High School, Delawares first high school for African-Americans, established. |
| 1868 | The 14th Amendment of the U.S. Constitution guarantees equal protection for all races under the law. The Delaware legislature votes against the amendment. |
| 1869 | First woman suffrage convention in Delaware |
| 1870 | First ocean resort opens at Rehoboth Beach. |
| The Fifteenth Amendment guarantees blacks the right to vote. The Delaware legislature votes against the amendment. | |
| Wilmington's African American community honors Thomas Garrett for his work as a stationmaster on the Underground Railroad. | |
| 1872 | Coeducation introduced at Delaware College, discontinued in 1885. |
| 1875 | State legislature creates separate schools with separate funding for white children and African American children. |
| 1876 | Indian River Lifesaving Station is built, the nations oldest station still on its original site. |
| 1878 | First telephone line installed in Wilmington. |
| 1880 | Dynamite and nitroglycerine manufactured by DuPont Company. |
| Rehoboth Beach holds what some claim is the first beauty contest in the nation. | |
| 1881 | County seat of New Castle County moves from New Castle to Wilmington. |
| First organized Jewish religious service in Delaware. | |
| 1882 | First electric street lights installed in Wilmington. |
| 1883-86 | Baltimore and Ohio Railroad extends through Delaware. |
| 1885 | Thomas F. Bayard appointed Secretary of State of the United States. |
| 1887 | Volunteer, a steel-hulled racing yacht, built in Wilmington, defeats Thistle to win Americas Cup. |
| 1888 | Electric street cars begin to replace horse cars in Wilmington. |
| 1889 | Law passes prohibiting punishment of women at whipping post or pillory. |
| 1891 | State College for Colored Students (now Delaware State University) chartered; opened in 1892. |
| Delmar nearly destroyed by fire. | |
| 1893 | Thomas F. Bayard appointed first United States Ambassador to Great Britain. |
| Delaware receives "The Wedge," a small piece of land, in boundary dispute with Maryland. | |
| 1897 | New state constitution adopted; still in effect today. |
| Property qualifications for voter registration abolished. | |
| 1899 | The Delaware Corporation Law is passed. In time this law will make it easier for businesses to incorporate in Delaware than in other states. |
| 1900 | Illustrator Howard Pyle opens his art school in Wilmington. |
| Frank Stephens purchases 163 acres near Grubbs Corner to found single tax community of Arden. | |
| 1901 | Legislature ratifies 13th, 14th, and 15th Amendments to the United States Constitution. |
| 1905 | Delaware becomes last state to abolish use of the pillory. |
| 1907 | First automobile licensed in state. |
| Delawarean Emily Bissell introduces Christmas Seal into America. | |
| 1909 | State House restored and enlarged. |
| Ownership of Chesapeake and Delaware Canal transferred to federal government. | |
| 1911-24 | T. Coleman du Pont builds a highway running the length of the state and gives to State of Delaware. |
| 1911 | Upton Sinclair and Scott Nearing, along with others, arrested at Arden for playing games on Sunday. |
| 1913 | Womens College founded at Newark. |
| Hotel Du Pont and Playhouse open. | |
| Wilson Line ferry begins ferry service between Wilmington and Pennsville, N.J. | |
| 1914 | Women's College opens in Newark. |
| 1915 | Child Labor Law passes. |
| State Labor Commission created. | |
| 1917-18 | Nearly 10,000 Delawareans serve in World War I. |
| 1920 | Woman suffrage amendment narrowly fails adoption in legislature. |
| 1921 | Construction begins on Wilmington Marine Terminal, completed 1923. |
| 1923 | Cecile Steele begins Delawares broiler chicken industry. |
| 1926 | Cape Henlopen Lighthouse collapses. |
| 1929 | Louis L. Redding becomes first African-American lawyer in state. |
| 1933 | Legislative Hall completed. |
| Legislature votes to repeal prohibition amendment. | |
| 1934 | United States Supreme Court confirms Delawares claim to control Delaware River. |
| 1935 | U.S. Supreme Court rules that twelve mile arc that defines the Pennsylvania-Delaware line should be extended into the Delaware River, giving Delaware a few uninhabited acres attached to New Jersey. |
| Dr. Wallace Carothers, working at the DuPont Experimental Station, discovers Fiber 66, the first synthetic fiber. | |
| 1937 | Bombay Hook National Wildlife Refuge organized. |
| Delaware Park race track opens. | |
| 1938 | Tercentenary Celebration of landing of Swedes in Wilmington. |
| 1939 | DuPont Company opens first nylon plant in Seaford and nylon stockings exhibits at World Fairs in San Francisco and New York. |
| 1941-45 | 30,000 Delaware men and women serve in armed forces in World War II. |
| 1942 | Fort Miles created between
Lewes and Rehoboth Beach. Major air bases created at New Castle and Dover. |
| 1945 | Womens College merges with University of Delaware. |
| 1949 | First annual Delmarva Chicken Festival held. |
| 1950 | Delaware Court of Chancery orders University of Delaware to end segregation. |
| 1951 | Delaware Memorial Bridge opens first span linking Delaware to New Jersey. |
| 1952 | Chancellor Collins J. Seitz deemed Delaware's segregated schools to be separate and unequal, a position upheld by the U.S. Supreme Court in Brown v. Board of Education. |
| Last public whipping; this form of punishment was abolished in Delaware in 1972. | |
| 1963 | Delaware General Assembly outlaws racial segregation in public accommodations. |
| President John F. Kennedy opens Delaware Turnpike (Interstate 95; now John F. Kennedy Memorial Highway) completing a non-stop highway between Boston and Washington D.C. This was one of Kennedy's last public appearances. | |
| 1964 | Cape May- Lewes Ferry begins operation. |
| 1968 | Riots break out in Wilmington following assassination of Martin Luther King, Jr., prompting 10-month occupation of city by National Guard, the longest occupation in the country. |
| Second span of the Delaware Memorial Bridge dedicated. | |
| 1969 | Richard Petty wins the first NASCAR-sanctioned race at Dover Downs. |
| 1971 | The Delaware Coastal Zone Act prohibits construction of industrial plants on coastal areas. |
| 1975 | William "Judy" Johnson, a former Negro League baseball player, becomes states first player elected to the National Baseball Hall of Fame. |
| 1978 | Daniel Nathans wins the Nobel Prize in Medicine for his work with molecular hormones. |
| 1981 | The Financial Center Development Act passes, encouraging out-of-state banks to move headquarters to Delaware. |
| 1984 | S.B. Woo elected lieutenant governor, becoming the highest-ranking Asian-American official in the United States. |
| 1995 | Legislature approves use of slot machines at Dover Downs, Harrington, and Delaware Park. |
| Route 1 bridge over the Chesapeake and Delaware Canal opens. | |
| 1999 | Jacqueline Jones, a native of Christiana, wins prestigious MacArthur Genius Award. |
| 2000 | Ruth Ann Minner elected Delaware's first woman governor. |
| 2002 | Clean Air Act passed - ban on smoking in public places. |